Regenerative aesthetics marks a shift in how we approach ageing. Instead of simply masking wrinkles or restoring lost volume with traditional dermal fillers, regenerative treatments aim to activate the body’s natural healing processes,—stimulating collagen, elastin, and cellular repair from within.
This growing category includes advanced bio-stimulators like exosomes and polynucleotides, which work at a cellular level to rejuvenate skin quality, improve texture, and promote long-term skin health.
Why the Shift from Fillers to Bio-Stimulation?
From the age of 30, collagen production declines by about 1% each year. Over time, this leads to thinner, looser, and less elastic skin. Traditional fillers temporarily restore volume but do little to improve underlying skin quality.
Regenerative aesthetics, on the other hand, targets the root cause: skin that’s lost its structure and function. By encouraging natural collagen production, these treatments offer longer-lasting, more natural-looking results.
Exosomes: The Next Generation of Skin Regeneration
What are they?
Exosomes are microscopic extracellular vesicles (30–150nm) secreted by stem cells. Think of them as messengers: they carry growth factors, peptides, RNA, and proteins to nearby cells, triggering repair, regeneration, and increased collagen and elastin synthesis.
Benefits in aesthetics:
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Speeds up post-treatment recovery
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Reduces inflammation and redness
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Improves overall skin tone and texture
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Enhances hydration and elasticity
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Supports hair growth in scalp treatments
Polynucleotides: Collagen-Boosting DNA Chains
What are they?
Polynucleotides (often called PDRN) are chains of DNA fragments usually derived from salmon sperm. They act as bio-stimulators, encouraging fibroblast activity—the cells responsible for producing collagen, elastin, and hyaluronic acid.
Benefits:
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Hydrates and plumps the skin
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Reduces fine lines and improves elasticity
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Aids in wound healing and scar repair
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Especially effective under the eyes and on crepey skin
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Often used post-laser or microneedling to boost results
Popular for:
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Under-eye rejuvenation
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Facial skin boosters
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Neck, décolleté, and hand rejuvenation
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Acne scarring
Safety and regulation:
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Side effects are rare and typically limited to swelling or mild bruising
Combining Exosomes and Polynucleotides
Many clinics are now combining exosomes and polynucleotides for a synergistic effect. While PNs activate the skin’s regeneration response, exosomes amplify cellular communication and healing.
Common protocols:
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Microneedling with polynucleotides and exosome application
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Post-laser skin boosters with exosome-rich serums
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Scar and texture improvement using combination therapy
Results often include improved texture, faster healing, brighter complexion, and more consistent collagen remodelling over time.
The Rise of Regenerative Skin Treatments in Clinics
These advanced treatments are being used for:
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Under-eye wrinkles and hollowness
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Dull, dehydrated skin
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Post-acne scarring
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Skin laxity on the face and neck
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Post-treatment recovery (laser, microneedling, RF)
They’re especially suited for clients looking for subtle, gradual improvements without the ‘filled’ look. Many also use them to prevent signs of ageing before volume loss becomes more visible.
Are These Treatments Safe?
Generally, yes—when performed by a trained practitioner using high-quality, well-sourced products.
The Future of Aesthetics is Regenerative
The direction is clear: the aesthetics industry is moving beyond superficial fixes. Patients are increasingly seeking treatments that restore their skin’s integrity—not just its appearance.
Want to explore regenerative treatments?
Injectual offers polynucleotide and exosome-based therapies performed by expert aesthetic practitioners in our London studio. Book a consultation today to find the right treatment for your skin.
