Polynucleotide injections are one of the most advanced regenerative treatments in aesthetics today, offering remarkable improvements in skin texture, elasticity, and hydration. But as with any injectable, one common question is: how painful are they?
Let’s break down what to expect in terms of discomfort — and why it’s often less than you’d think.
What Are Polynucleotides?
Polynucleotides are bioactive molecules derived from purified salmon DNA. When injected into the skin, they stimulate fibroblast activity, boost collagen and elastin production, and enhance tissue regeneration.
They are used to treat:
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Under-eye hollows and dark circles
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Fine lines and crepey skin
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Acne scarring
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General loss of skin quality or hydration
What Does the Procedure Feel Like?
During the Treatment:
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Most patients describe the sensation as mild to moderate discomfort, not pain.
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A very fine needle is used.
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Numbing cream is typically applied beforehand to reduce sensation.
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The most sensitive area tends to be under the eyes, where the skin is thinner.
Sensation:
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You may feel a slight sting or pinch at the injection points.
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There can be mild pressure or heat as the product is introduced.
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Some clients compare it to mesotherapy or skin boosters — more noticeable than Botox, less painful than filler in bony areas.
How Long Does the Discomfort Last?
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Any stinging or tenderness subsides within minutes after the procedure.
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Post-treatment, some areas may feel slightly sore or tender for 1–2 days, especially if multiple passes were made.
Can You Make It Less Uncomfortable?
Yes. At Injectual, we minimise discomfort by:
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Applying medical-grade topical anaesthetic
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Using gentle injection techniques with precision
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Offering cooling or soothing serums post-treatment
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Injectual provides advanced pain management options, including local lidocaine injections, for clients who prefer extra comfort
Are Polynucleotides More Painful Than Botox or Fillers?
In general:
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Botox is the least painful — quick, shallow injections with little to no discomfort.
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Filler can be more intense due to product thickness and depth of placement.
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Polynucleotides sit somewhere in between — slightly more than Botox, much less than tear trough filler.
Summary
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Polynucleotide injections involve mild to moderate discomfort, typically well tolerated.
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Numbing and technique reduce pain significantly.
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Under-eye treatments may be more noticeable, but still manageable for most patients.
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Recovery is easy, with little to no lingering pain.
Considering Polynucleotides?
At Injectual, we specialise in advanced skin regenerative treatments — including our proprietary Polynucleotide Cocktail, designed for powerful yet natural results.
If you’re concerned about discomfort, we’ll walk you through every step and tailor your treatment for maximum comfort and results.
Book your consultation to find out if polynucleotides are right for you.
