Polynucleotides are a breakthrough in regenerative aesthetics, known for their ability to improve skin quality, elasticity, and hydration. But one question patients often ask is:
Are polynucleotides really made from fish?
The short answer: Yes most polynucleotide injectables are derived from fish DNA, but it’s more sophisticated than it sounds.
What Are Polynucleotides Made From?
Polynucleotides are highly purified strands of DNA fragments extracted from salmon or trout sperm. This source is rich in biocompatible nucleic acids that mimic the body’s own DNA, making them ideal for regenerative use.
However, it’s important to note:
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The final product contains no whole cells, proteins, or allergens typically associated with fish.
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The DNA is purified, fragmented, and stabilised through rigorous laboratory processes.
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What’s injected is a sterile, medical-grade substance specifically engineered for skin regeneration not raw fish extract.
Why Salmon DNA?
Salmon DNA is biologically similar to human DNA and has a low risk of triggering immune reactions. It’s:
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Highly biocompatible
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Non-immunogenic
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Rich in regenerative potential
Its properties make it ideal for:
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Stimulating fibroblasts (collagen and elastin production)
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Improving skin hydration and texture
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Accelerating tissue repair and healing
Is It Safe?
Yes. Polynucleotides undergo extensive purification to ensure they are:
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Free of proteins, which are more likely to cause allergic responses
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Sterile and stable, meeting strict medical standards
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Suitable for even sensitive areas, such as under the eyes
They are considered very safe, with minimal risk of side effects particularly compared to other biologically derived products.
Are There Vegan or Plant-Based Alternatives?
Currently, no plant-based polynucleotide treatments exist that offer the same regenerative effects. If you're concerned about the origin, this is something to discuss in consultation but for now, fish-derived polynucleotides remain the gold standard.
Summary
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Yes, polynucleotides are typically derived from salmon or trout sperm DNA.
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The DNA is purified and processed into a completely safe, non-allergenic injectable.
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It contains no fish proteins or raw material only the therapeutic DNA fragments.
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This natural source offers superior regenerative benefits with excellent safety and tolerance.
Want to Know More?
Injectual offers some of the London’s most advanced polynucleotide treatments. If you have questions about ingredients or suitability, our expert team will guide you through everything you need to know.
Book a consultation today to explore regenerative skincare, backed by science.
