Advanced Regenerative Skin Rejuvenation in London
The Injectual Polynucleotide Cocktail XL is our most advanced regenerative injectable treatment, designed to restore skin quality, resilience, and radiance at a cellular level. This enhanced protocol combines multiple polynucleotide formulations with skin-boosting actives to deliver intensive tissue repair, collagen stimulation, and long-term skin health, without adding volume.
Developed and refined by Injectual, the Polynucleotide Cocktail XL represents a next-generation approach to aesthetic medicine, prioritising biological skin regeneration, skin strength, and longevity.
What Is the Injectual Polynucleotide Cocktail XL?
The Injectual Polynucleotide Cocktail XL is a medical-grade injectable protocol that activates the skin’s natural regenerative processes. It uses highly purified polynucleotides, derived from DNA fragments, to stimulate fibroblast activity, enhance collagen and elastin production, and improve overall skin integrity.
The XL protocol delivers a higher regenerative impact by combining multiple polynucleotide products in a single treatment session, making it particularly effective for advanced skin ageing, compromised skin quality, and intensive rejuvenation.
What’s Included in the Polynucleotide Cocktail XL?
At the core of the Polynucleotide Cocktail XL are PLINEST® Eyes and PLINEST® Skinbooster, clinically established polynucleotide injectables used extensively in regenerative and aesthetic medicine.
These polynucleotides work by:
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Stimulating fibroblast activity
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Enhancing collagen and elastin synthesis
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Accelerating tissue repair and regeneration
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Improving firmness, elasticity, and hydration
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Strengthening the skin barrier
PLINEST Eyes is designed for delicate areas, while PLINEST Skinbooster targets larger areas requiring structural skin improvement.
NEWEST® by Dermafocus
The XL protocol also incorporates NEWEST® by Dermafocus, which enhances hydration, skin density, and luminosity. Used alongside polynucleotides, it supports the regenerative environment and improves overall skin texture and radiance.
Injectual Proprietary Nutrient Blend
To maximise outcomes, the Polynucleotide Cocktail XL includes a bespoke Injectual blend of essential nutrients, including vitamins, amino acids, and hyaluronic acid. This proprietary formulation is designed to support collagen production, improve skin quality, and promote long-term skin health.
Polynucleotides & “Salmon Sperm” Treatments: What You Should Know
Polynucleotide treatments are often referred to online as “salmon sperm facials.” This is a consumer-led term used to describe regenerative treatments derived from fish DNA.
At Injectual, the Polynucleotide Cocktail XL uses highly purified polynucleotides derived from trout DNA, not salmon. Trout DNA is chosen for its high biocompatibility with human skin, excellent safety profile, and proven regenerative properties.
These DNA fragments are extensively purified and processed to ensure they are safe, sterile, and suitable for medical aesthetic use. The resulting polynucleotides work by:
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Supporting cellular repair and regeneration
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Stimulating collagen and elastin production
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Improving skin resilience and texture
While the “salmon sperm” term is commonly used in popular media, the science behind the treatment is polynucleotide therapy, and the clinical results are based on regenerative medicine—not cosmetic trends.
What Skin Concerns Does the Polynucleotide Cocktail XL Treat?
The Injectual Polynucleotide Cocktail XL is particularly effective for:
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Dull, tired, or stressed skin
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Fine lines and early to moderate signs of ageing
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Loss of firmness and elasticity
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Dehydrated or compromised skin
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Uneven texture and tone
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Skin requiring intensive repair or rejuvenation
It is ideal for clients seeking natural, progressive skin improvement without fillers or volumisation.
Treatment Plan & Course Recommendations
The Injectual Polynucleotide Cocktail XL can be performed as a stand-alone treatment, however for optimal regenerative results, a course of three treatments is recommended.
Your clinician will tailor the treatment plan following a full consultation and skin assessment.
Book a Polynucleotide Cocktail XL Consultation
To find out whether the Injectual Polynucleotide Cocktail XL is right for you, book a personalised consultation with our medical team. We will assess your skin, discuss your goals, and design a bespoke regenerative treatment plan.